Formulation of self-microemulsifying drug delivery system (SMEDDS) of ibuprofen for oral delivery

Background: In the Biopharmaceutical Classification System (BCS), ibuprofen (IBU) belongs to Class II (poorly soluble, well-absorbed), which limits its therapeutic effectiveness due low bioavailability. Currently, self-microemulsifying drug delivery systems (SMEDDS) are used stabilize compounds and enhance solubility absorption of poorly soluble absorbable drugs. Therefore, objective this study was develop characterize a SMEDDS formulation containing IBU for oral administration. Materials methods: The utilized (from China), various oils (such as oleic acid, Peceol, etc.), surfactants Acrysol EL-135, K-140, co-surfactants propylene glycol, Lauroglycol 90). investigated selected appropriate excipients their ratios optimize formulation, evaluated aspects such appearance, emulsification capacity, droplet size, size distribution, content. Results: results showed that IBU-containing consisted 8.7%, Capryol EL-135 66.08%, glycol 16.52%, with 16.33 ± 0.124 nm PDI 0.185 0.003. It is capable rapid self-emulsification within 30 seconds gentle stirring distilled water (with volume ratio 1:500, v/v) form clear microemulsion. Conclusion: conclusion, successfully developed IBU, shows promise development an dosage form. Key words: Ibuprofen, Self-microemulsifying system, delivery.